Yarmouthport resides in the town of Yarmouth, which was settled in 1639 as a rural community with residents making their living from farming, fishing and salt evaporation. Like many towns of that era, Yarmouth was much larger then, encompassing the town of Dennis. Native Americans of the Wampanoag nation lived here long before the Europeans settled here, in this place they called Mattacheese.
The mid-1800s and the railroad link from Boston brought about the first influx of seasonal visitors. Today, tourism is still the predominant industry in Yarmouth and all of Cape Cod. Today, Yarmouth's population triples each summer with arrival of summer visitors. Yet, in spite of offering all the modern conveniences and development in certain areas, Yarmouth has retained much of its old fashioned charm in its villages of Bass River, South Yarmouth, West Yarmouth and Yarmouth Port.